Evaluation of Lipid Profile and Intima Media Thickness in Antiretroviral-Experienced HIV-Infected Patients Treated with Protease Inhibitor-Based Regimens versus Protease Inhibitor-Sparing Regimens

Background: Antiretroviral therapy has increasingly improved management of HIV infection, ensuring long-term efficacy and tolerability. Each class antiretrovirals has, however, different characteristics tolerability profiles. The literature data show that protease inhibitors (PIs) are associated with a higher incidence dyslipidemia. aim our study was to evaluate whether patients treated PIs have both greater dyslipidemia increased intima media thickness (IMT) atheromatous plaques compared without PIs. Materials Methods: A total 110 HIV-experienced screened Doppler ultrasonography the supra-aortic trunks in December 2019 were enrolled retrospective cross-sectional observational study. Patients divided into two groups: 59 PI-based group, PIs, 51 PI-sparing group. In groups, we evaluated lipids, cardiovascular risk factors (smoking, BMI, age, hypertension), pathological IMT (a value > 1 mm), possible plaque. Results: Serum LDL (p 0.04) percentage hypercholesterolemia 0.03) than showed trend increase which appeared statistically significant for section left common carotid artery 0.03). However, multivariate logistic regression models, none variables significantly 1. Conclusions: Our real-life developing These findings may be useful optimize factors.